Stephen M. Smith
The major theme of our lab is rapid neuronal signaling in the mammalian brain and how this changes in disease states. Focusing mainly on the cerebral cortex, we study regulation of intrinsic excitability and synaptic transmission. A major target is the calcium sensing receptor (CaSR) which has been identified in neuronal somata and terminals.
Another interest has been heterogeneity of synaptic transmission at excitatory synapses and in particular the different roles of voltage-activated calcium channels (VACCs) at excitatory and inhibitory synapses.
Grew up in Nottingham, England.